*Disclaimer: Just because you can’t take CBD orally, doesn’t mean you can’t fuel the endocannabinoid system! While some may not be able to use capsules, tinctures, or edibles – there are other options such as healing bath salts, topicals (salves/lotions), suppositories, and transdermal patches!


Photo by Peter Gombos on Unsplash

Mixing CBD and pharmaceuticals?

Fueling the endocannabinoid system is likely be of great benefit to those most in need of pharmaceutical meditation. Yet, while most pharmaceuticals are fine to take alongside cannabinoids, there are some potential issues that are very important to be aware of.

If taking a medication that is digested by the CPY3A4 family of liver enzymes, consuming CBD orally may not be a good option. CBD temporarily inhibits Cytochrome P450, which metabolizes up to 65% of the pharmaceutical medications people consume. Therefore, when this digestive process takes place, the body will most likely break down the CBD rather than the
pharmaceutical, which can cause the pharmaceuticals to build up in the body, and an overabundance of pharmaceuticals in the body can lead to exaggerated, unwanted, and potentially harmful effects.

How can I tell if this is my medication?

Of course, it is best to talk to your doctor. CBD is a deeply therapeutic, truly changing body at a cellular level, and should be discussed with a medical professional as any medication would be. Studies are underway to determine which medication CBD should and should not be mixed with—but we have a fairly standard rule—if you can’t take grapefruit while on the medication?
You probably shouldn’t take CBD orally. In grapefruit, there is a chemical, furanocoumarins, which inhibits the CYP3A4, similar to CBD. Let me repeat myself: Just because you can’t take CBD orally, where it will go through the digestive tract (including the liver), doesn’t mean you can’t take CBD!! There are many delivery mechanisms, such as those listed below, which can provide relief while working to resupply the endocannabinoid system. Here is a list, put out by Penn State, of medications which should be closely monitored while taking CBD. This list is not extensive, so always remember the grapefruit rule!

There are other options to help fuel the endocannabinoid system!!


Photo by Maddi Bazzocco on Unsplash

Those who have skin difficulties/joint issues:

Topicals. (Anything you put on your skin, including patches and bath salts.)

Studies have shown when CBD is applied topically, it results in a meaningful accumulation of cannabinoids in the skin and the underlying muscle. Additionally, this delivery mechanism is extremely bioavailable, provides the ability to target specific areas of the body, and serves as support for issues ranging from inflammation and circulation to dryness.

Those who have muscle aches/nerve problems/stomach issues:

Bath Salts.

My all time favorite products! When the skin heats up and soaks in all of the cannabinoids, it’s
nothing short of divine.


With a 90% bioavailability rate, the highest there is, there’s no wonder these are the most
in-demand and re-ordered products around. They stay on the body for up to 92 hours with a slow
but steady release of cannabinoids.

CBD Suppositories.

Not only do these go directly into the bloodstream, but they are also extremely supportive for
those suffering from lower body pain.

Leave a Reply

Your email address will not be published.