CBG: The Preemptive One
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How does CBG work? Both CBD and CBG have 65 known targets outside of the endocannabinoid system. This means that modifying the endocannabinoid system is only a small portion of the action these compounds take in the body. There are other chemical activities these cannabinoids stimulate, such as expression of glycine, GABA, GPRSS, 5-HTIA & HT2A, PPAPy, adenosine, opioid, and GPR18 pathways to name a few. CBG is especially known to turn on serotonin feedback. Cannabinoids help the body produce its own serotonin, unlike medications, which produce serotonin for the body, causing the body to think “oh, we have enough!” and stop producing serotonin on its own.
CBG for the gut? A study by Francesca Borrelli, et al., called Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease, found that CBG has the ability to reduce a dysregulation of intestinal microbial communities through first, reducing nitric oxide production in macrophages (the main player in chronic gut inflammation), and, second, lowering the ROS formation in the intestinal cells (an overproduction of Reactive Oxygen Species in the cells can create many physiological and pathological conditions, including conditions of the gut).
CBG for neuroinflammation? Current literature suggests that it is extremely important to continue studying CBG for neuroinflammatory complications. Due to this cannabinoid’s ability to protect neuronal cells from an overactivated PPARγ, a release of inflammatory mediators in microglial cells is inhibited. This interaction with the spine and the brain is how cannabinoids are able to modulate pathophysiology, such as in the case of those who suffer from losing control of the body, or those with impaired coordination.
What is this cannabinoid most famous for? CBG is extremely well known to help those suffering with pressure on the eyes and issues around the eyes. Additionally, it is seen as the optimal cannabinoid to retain health at a cellular level, especially in terms of reducing malignant cell growths.
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CBDA: The Potent One
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How does CBDA work? Instead of binding directly with the cannabinoid receptors, CBDA inhibits the COX-2 enzymes. These enzymes are associated with inflammation after either injury or infection. This is how CBDA reduces pain by healing the body.
What’s cool about CBDA? It is a more bioavailable cannabinoid! It has an enhanced effect and its presence enhances the effectiveness of all other cannabinoids present. This means it’s extremely effective at a minute dose.
Fun fact about CBDA? While many cannabinoids with the C in front of them (such as CBD) create focus and reduce the effects of the cannabinoids that begin with a T (such as THC), CBDA does not reduce the effects of THC.
Reduce the nausea? Studies have illustrated that CBDA is not only good at reducing nausea, but it is particularly good at reducing medically induced nausea and vomiting.
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CBC: The Protective One
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CBC for the brain? CBC fosters neural stem progenitor cells working more effectively. These are the most important cells for maintaining brain homeostasis because they turn into astroglial cells. These cells prevent oxidative stress, inflammation, and toxicity in the brain. This is extremely important if a person has a predisposition to neurological diseases. Additionally, CBC is known for its antidepressant properties.
Prevention for the cells? Just after CBG, CBC is the second most potent fighter against malignant cell formation—this is an extremely powerful discovery, not only to heal the sick, but also to utilize as an important preventative measure before the cells have become oxidized and malignant.
CBC for the gut? Studies have concluded that CBC plays an important role in normalizing food digestion. An Italian study Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice by Izzo, AA, et al. found that, in rats, CBC normalized gut motility, but not through the endocannabinoid system. Rather, this is achieved by influencing mRNA expression of TRPV1 receptors—this is why further studies are needed. Perhaps this is a doorway into what the entourage effect and these less abundant cannabinoids are all about. The endocannabinoid system is amazing and potent, but it is still shrouded in mystery.
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